Determination of Amphetamine and Methamphetamine by Dispersive Liquid Phase Micro-extraction: A Novel Experimental Approach
نویسندگان
چکیده مقاله:
Background: A syringe to syringe dispersive liquid phase micro-extraction-floating organic drop was applied and used for the simultaneous extraction and pre-concentration of trace amounts of amphetamine (AMP) and methamphetamine (MAMP) in urine samples. The extracted analytes were determined by high performance liquid chromatography along with diode array detection. Materials & Methods: In this study, n-hexane was selected as the extraction solvent without the need to use dispersive solvent. The analytical parameters affecting the micro-extraction efficiency, including pH of sample solution, extraction solvent volume, the cycles of extraction and time of centrifugation were investigated and optimized by screening and optimization experimental design methods. Results: Underoptimal conditions, the calibration curve had a linear range of 2 to 100 μg/L with the determination coefficient of R2 = 99.8 and R2 = 99.6 for AMP and MAMP, respectively. The limit of detection was 2μg/L for AMP and MAMP, and the enrichment factor was 75 and 68 for AMP and MAMP, respectively. Conclusions: This method is very simple, rapid and has been successfully used for pre-concentration and measurement of the analytes in urine samples, which is important to forensic studies.
منابع مشابه
Pre-concentration and Determination of Low-traces of Copper Ions in Different Mediums Using Dispersive Liquid-liquid Micro-extraction (DLLME)
In the paper, in order to pre-concentrate and measure the low values of Cu ions, the new, simple,quick and very sensitive method of Dispersed Liquid-Liquid Micro Extraction (DLLME) coupledwith flame Atomic Absorption spectrometry (AA) has been utilized. The DLLME techniquecoupled with AA )AA-DLLME) was run inside one narrow tube which constitute aqueous samples.In this m...
متن کاملdetermination of endosulfan in water samples using dispersive liquid-liquid micro-extraction and experimental design for optimization
water contamination due to the wide variety of pesticides used in agriculture is a global environmental pollution problem. in order to reach at sub-î¼gl-1 levels of detection, an efficient extraction technique is required. a simple, fast and economical method, dispersive liquid-liquid micro extraction (dllme), followed by gas chromatography-mass spectrometry was assessed for determining endosul...
متن کاملDetermination of Iron Species by Combination of Solvent Assisted-Dispersive Solid Phase Extraction and Spectrophotometry
A simple, rapid and sensitive solvent assisted-dispersive solid phase extraction method was developed for the extraction of iron(II) prior to its spectrophotometric determination. The Fe(II) reacted with 2,4,6-tris(2-pyridyl)-1,3,5-triazine, neutralized with sodium dodecyl sulfate and extracted onto the fine particles of benzophenone which were formed upon rapid injection of a mixture of benzop...
متن کاملdevelopment of a dispersive liquid-liquid micro-extraction (dllme) method for preconcentration and determination of al in biological fluids
متن کامل
Experimental Investigation of Phase Inversion of Liquid-Liquid Systems in a Spray Extraction Column
An experimental study of the phase inversion behavior of liquid-liquid dispersion has been conducted in a spray extraction column for systems of toluene / water, n-hexane/water, CCl4/water, toluene /water + glycerol (25 % wt), toluene + CCl4 (25 % wt) / water and toluene / acetic acid (5 % wt)/water. The effects of physical properties, mass transfer and column geometry...
متن کاملEvaluation of thallium rate in soil after dispersive liquid-liquid micro-extraction
Thallium is widely found in nature, but the only inorganic stones full of this element are crookesite and lorandit. It isalso found in pyrites of copper, lead and inorganic stones. The element and its compositions are toxic and harmful to theenvironment; therefore, its application requires caution and further research. It is important to develop sensitive andaccurate analytical methods to deter...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 14 شماره 4
صفحات 0- 0
تاریخ انتشار 2020-10
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023